PROteolysis – TArgeting Chimeras (PROTACs) are a series of hetero-bifunctional molecules that hijack the body’s own natural disposal system to initiate selective degradation of the protein of interest (POI). PROTACs have the potential to overcome most of the limitations of small molecule inhibitors, while offering several advantages of the traditional concepts of drug discovery. Aurigene offers expertise in all niche modalities related to PROTACs and molecular glues for targeted protein degradation, including stand-alone Chemistry, Biology (in vitro, in vivo pharmacology and toxicology) and DMPK services to fully integrated drug discovery programs.
We have extensive experience in not only the synthesis and purification of PROTACs but also the capability of extensively profiling our synthesized PROTACs including various biological assays, in addition to a full-spectrum ADME and PK services tailored to PROTAC molecules. We are uniquely poised in the Indian CRO market not only as a key player with extensive knowledge in small molecule-based Drug Discovery research but also can offer our significant experience on the PROTAC-related domain to any potential collaborators.
We are well versed in the synthesis and functionalization of various E3-ligase ligands such as CRBN, VHL, MDM2, AhR, and cIAP1 (in multi-gram scale) and in the synthesis of commercially available ligands, as well as in developing novel structural analogues as per custom requests like open CRBNs. We also have significant experience in the related fields of Targeted Protein Degradation (TPD) such as molecular glues, ATTECs, AUTECs, HyTs and in niche modalities like Oligo-PROTACs, Peptide-PROTACs, etc. We also offer a partial PROTAC library of ~500 entries as a quick plug-and-play for PROTAC development from a POI-ligand of choice.
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