What is potassium diformate? Can it really replace antibiotics used ...

As the saying goes: "The people take food as the heaven, and the livestock takes the feed first." People cannot survive without food, and livestock cannot survive without food. Feed is the material basis for animal growth, reproduction and production, and it is also the main factor that determines the productivity of the aquaculture industry. The feed additive potassium diformate has obvious effects on strengthening the nutritional value of basic feed, improving animal production performance, ensuring animal health, improving feed conversion efficiency and improving the quality of livestock products.

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The green and high-quality development of animal husbandry is inseparable from the application of feed and feed additives. There are actually many products that can be replaced now. After the advent of anti-antibiotics, there will be a variety of Chinese medicine preparations, essential oils, and a hundred flowers blooming. Are these things effective? Yes. But it's certainly not as straightforward as antibiotics. This also requires how to improve hardware and management methods.

Potassium diformate was originally one of the effective solutions to replace the role of antibiotic growth-promoting agents in European countries in the early use of anti-antibiotics. With the implementation of the anti-resistance policy of my country's feed and the continuous tightening of resistance reduction measures in the breeding industry chain, the current overall demand and market space for potassium diformate will gradually open up.

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In fact, potassium diformate is a new type of antibiotic growth promoter substitute product. It is not only highly acidic, but also slowly released in the digestive tract. It has a high buffering capacity and can avoid excessive fluctuations in the acidity of the animal's gastrointestinal tract.

The main components of potassium diformate, formic acid and potassium formate, exist naturally in nature and in the intestines of pigs. They are finally metabolized and decomposed into CO2 and water, which are completely biodegradable. Therefore, potassium diformate can effectively improve the digestion and absorption of nutrients by farm animals, increase the utilization rate of feed protein, and reduce nitrogen emissions.

Therefore, in the process of livestock feeding and production, potassium diformate as the green and healthy feed additive can not only promote the rapid growth of livestock and poultry, but also promote the green, healthy and high-quality development of animal husbandry.

Contact us to discuss your requirements of Potassium diformate in livestock nutrition. Our experienced sales team can help you identify the options that best suit your needs.

A short review on the use of potassium-diformateRoutine use of antibiotics as growth promoters is a matter of debate in the animal farming industry. The use of low levels of these antibiotics in animal feeds possesses the possibility to transfer bacterial immunity to species pathogenic in animals and humans (Liem ). The EU has banned all antibiotic growth promoters (AGP) from livestock production with effect of January . Public opinion and regulation authorities in most of the export countries focusing now on the misuse of antibiotics in aquaculture and public attention have shifted towards production methods. Therefore, alternatives to AGP are worldwide sought in a variety of forms. Acidifiers consisting of organic acids and their salts present a promising alternative and they have received much attention as a potential replacement in order to improve the performance and the health of treated animals. In animal nutrition, acidifiers exert their effects on performance via three different ways (Freitag ): (a) in the feed; (b) in the gastro-intestinal tract of the animal; and (c) due to effects on the animal‘s metabolism.The beneficial effects of acid preserved products caught the attention of the scientific community to investigate the effects of these short-chain acids onto the fish feed directly. In recent years the use of acidifiers in fish nutrition got more popular (see the review paper - Lückstädt ). Several studies have been especially conducted with potassium-diformate (a double-salt of formic acid) in herbivorous filter feeders like tilapia.Ramli et al. () tested potassium diformate (potassium salt of formic acid) as a growth promoter in tilapia grow-out in Indonesia (Table 1). In this study, fish were fed over a period of 85 days 6 times a day diets containing different concentrations of potassium diformate (0%, 0.2%, 0.3% and 0.5%). The diets contained 32% crude protein, 25% carbohydrates, 6% lipids and 10% fibre. The fish were challenged orally starting day 10 of the culture period with Vibrio anguillarum at 105 CFU per day over a period of 20 days.Table 1: Effects of potassium diformate supplementation in diets on performance of tilapia challenged with V.anguillarum (modified from Ramli et al. )Over the entire feeding period from day 1 to 85, potassium diformate significantly increased feed intake (P< 0.01) and weight gain (P< 0.01) as well as improved the feed conversion ratio significantly (P< 0.01). Furthermore, protein efficiency ratio was also significantly improved due to the addition of the formic acid salt (P< 0.05). The improvement was best with 0.2% and 0.5% addition of the formate. Survival rates of fish after the challenge with V. anguillarum on day 10 were also significantly higher compared to the negative control and the effect was dose dependent (P< 0.01). The authors concluded that the application of potassium diformate at 0.2% is an efficient tool to control bacterial infections in tropical tilapia culture. Similar results were achieved by Zhou et al. (), who tested hybrid tilapia (Oreochromis niloticus x Oreochromis aureus) fingerlings (2.7 g initial weight) in a dose response study with potassium diformate (0%, 0.3%, 0.6%, 0.9% and 1.2%), while also comparing the results with an antibiotic growth promoter (8 mg / kg Flavomycin). During the 56 day trial period, tilapia fed all the potassium diformate enriched diets grew faster than the negative control (an increase of up to 11.6%), while fish fed 0.3% and 0.6% potassium diformate achieved even better weight gain than the fish in the positive control group. The authors speculated that dietary potassium diformate could stimulate a beneficial bacterial colonization of the intestine. The latest study with this highly effective substance was carried out in Malaysia (Ng et al. ). There, a 14-week feeding trial was conducted to determine the effect of dietary organic acids. The experimental diet was added with 0.2% of potassium diformate and fed to triplicate groups of red hybrid tilapia. Upon completion, tilapias were challenged with Streptococcus agalactiae. Results clearly showed that total bacteria per gram of faeces were significantly reduced in diets containing potassium diformate. The number of adherent gut bacteria tended to be lower as well. Furthermore, apparent digestibility of phosphorous was improved too - by nearly 11% in acidified diets. Finally, cumulative mortality of fish fed no organic acids (58.3%) was higher compared with fish fed the potassium diformate supplemented diet (16.6%) at 16 days post challenge (Figure 1). The Malaysian data showed that the inclusion of this acidifier can exert strong antimicrobial effects and have the potential to exert beneficial effects on nutrient utilization as well as disease resistance in tilapia. Organic acid salt may be therefore especially during the grow-out period of high importance for tilapia culture (Lückstädt ).Fig. 1: Mortality in tilapia post challenge with Streptococcus agalactiae fed with or without Aquaform (potassium diformate)ConclusionesResults from the aforementioned studies indicate promising potential and compel aqua feed manufacturers to consider using acidifiers in their diets. The use of acidifiers, especially of potassium diformate in tilapia, will be an efficient tool to achieve sustainable, economical, and safe fish production.