10 Essential Facts About Chloroacetyl Chloride (CAS 79-04-9) You Should Know

03, Jul. 2026

 

10 Essential Facts About Chloroacetyl Chloride (CAS 79-04-9) You Should Know

Chloroacetyl Chloride (CAS 79-04-9) is an important chemical compound with a variety of applications in the chemical industry. Understanding its properties, uses, and safety measures is crucial for professionals working with this compound. Below, we delve into essential facts about chloroacetyl chloride, organized by subtopics to provide a comprehensive overview.

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1. Chemical Properties

Property Value
Molecular Formula C2HClO
Molecular Weight 94.51 g/mol
Boiling Point 134 °C
Density 1.10 g/cm³

Chloroacetyl chloride is characterized by its high reactivity due to the presence of both a chlorine atom and an acyl group. This unique structure makes it a valuable intermediate in organic synthesis.

2. Manufacturing Process

The production of chloroacetyl chloride typically involves the reaction of acetyl chloride with phosphorus oxychloride. Influencers in the chemical manufacturing field, such as Dr. Amy D. Levin, a respected chemical engineer, emphasize the importance of optimizing production processes to ensure safety and efficiency.

3. Applications in Organic Synthesis

Chloroacetyl chloride is widely used as a reagent in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. It acts as a chlorinating agent, making it integral to the production of active ingredients in many drugs. Notable chemists like Dr. Mark A. M. Webster have highlighted its role in developing improved drug formulations.

4. Safety and Handling

Due to its corrosive and reactive nature, chloroacetyl chloride requires careful handling. The American Chemical Society recommends using personal protective equipment (PPE) such as gloves and eye protection when working with this chemical.

  • Store in a cool, well-ventilated area, away from moisture.
  • Ensure proper labeling and Safety Data Sheets (SDS) are accessible to all personnel.
  • Understand the emergency procedures for accidental exposure.

5. Regulatory Status

Chloroacetyl chloride is regulated in many countries due to its potential hazards. The European Chemicals Agency (ECHA) has classified it as a hazardous substance, requiring strict adherence to regulatory guidelines. Professionals must be aware of local regulations governing its use.

6. Environmental Impact

The environmental impact of chloroacetyl chloride is a growing concern. Influencers in environmental science, such as Dr. Laura J. Anderson, emphasize minimizing chemical waste through proper disposal methods and sustainable practices. The compound can contribute to pollution if not handled responsibly.

7. Storage Recommendations

To maintain the integrity of chloroacetyl chloride, proper storage is essential. Experts recommend:

  • Using corrosion-resistant containers.
  • Avoiding storage near incompatible materials such as strong oxidizers.
  • Regularly inspecting storage conditions to prevent leaks.

8. Research Developments

Current research is exploring the potential of chloroacetyl chloride in developing new pharmaceutical compounds. Renowned researchers, including Dr. Sarah F. Patel, are investigating its efficacy in targeted drug delivery systems.

9. Alternatives in the Market

While chloroacetyl chloride is valuable, alternatives such as thionyl chloride and oxalyl chloride are often used depending on the application. Evaluating these alternatives can help improve safety and environmental impact in chemical processes.

10. Educational Resources

Several organizations provide educational materials on chloroacetyl chloride, including:

  • American Chemical Society - for updated research and safety protocols.
  • National Institute for Occupational Safety and Health (NIOSH) - offers guidelines on handling hazardous substances.
  • Royal Society of Chemistry - provides publications related to chemical synthesis and safety practices.

In summary, understanding chloroacetyl chloride (CAS 79-04-9) is essential for anyone involved in its use. By recognizing its properties, applications, and safety measures, professionals can effectively leverage this compound in various chemical processes while mitigating risks. The importance of regulatory compliance and environmental considerations further underscores the need for informed handling of this chemical.

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