4-Hydroxycyclohexanone Ethylene Acetal CAS 22428-87-1: Properties, Uses, and Sourcing Guide
4-Hydroxycyclohexanone ethylene acetal, CAS 22428-87-1, is a protected cyclohexanone building block with a free hydroxyl group. Its ketone is converted into an ethylene acetal, while the hydroxyl remains available for further chemical transformation. This combination can make the compound useful in multistep organic synthesis, including research and intermediate-development work. Below, we explain its identity, potential applications, specification checks, and practical sourcing considerations.
Who This Guide Is For
This guide is for chemical buyers, process chemists, research teams, and procurement professionals evaluating 4-Hydroxycyclohexanone ethylene acetal for a defined synthesis or development project. It is intended to support initial product evaluation rather than replace a project-specific technical review. Before purchasing, buyers should confirm that the supplier’s identity information and batch documentation match their intended use. Requirements for research, scale-up, and regulated manufacturing may differ substantially.
Basic Concept and Chemical Context
An ethylene acetal is a cyclic protecting group formed from a carbonyl compound and ethylene glycol. In this molecule, the acetal masks the cyclohexanone carbonyl, while a separate hydroxyl group remains unprotected. The two functional features provide different possible reaction handles, but their value depends on the buyer’s planned chemistry and process conditions.
Identity and Structural Overview
The product is commonly described by the name 4-Hydroxycyclohexanone ethylene acetal and the registry number CAS 22428-87-1. The corresponding molecular formula is C8H14O3, with a calculated molecular weight of approximately 158.20 g/mol. These identifiers are useful for initial screening, but buyers should still verify the name, CAS number, and analytical data on the lot-specific documents they receive.
| Item | Information | Buyer relevance |
|---|---|---|
| Product name | 4-Hydroxycyclohexanone ethylene acetal | Use the same identity wording in the inquiry and purchase documents. |
| CAS number | 22428-87-1 | Confirm it against the supplier’s specification and certificate of analysis. |
| Molecular formula | C8H14O3 | Useful for checking consistency with the proposed structure. |
| Calculated molecular weight | Approximately 158.20 g/mol | Useful for stoichiometric calculations and documentation review. |
Potential Uses and Application Matching
The compound may be considered as a synthetic building block when a route requires a cyclohexane framework with a protected carbonyl and an available hydroxyl group. A chemist may use the protected carbonyl to manage reaction selectivity while transforming the hydroxyl or other parts of the molecule. Whether the protecting group is suitable depends on the planned reaction sequence, including the conditions needed to install, retain, or remove it.
Research and Intermediate Development
For laboratory research, a buyer may assess the material in route scouting, reaction screening, or the preparation of a downstream intermediate. In pharmaceutical or other specialty-chemical development, it may be evaluated as a starting material or intermediate candidate, but suitability cannot be assumed from the name alone. The project team should confirm compatibility with its own route, impurity limits, and analytical methods before moving to a larger quantity.
Match the Product to the Process
Begin by identifying which functional group must remain protected and which one must be available for reaction. Then compare the planned conditions with the stability requirements of an ethylene acetal and the free hydroxyl group. If the route involves conditions that may affect either group, request technical information and run a small-scale compatibility assessment before committing to production quantities.
Specification and Material Review
Do not assume a physical-property value, purity, or storage condition unless it is confirmed in the current supplier documentation. For this product, ask for the available specification and lot-specific certificate of analysis, and check which analytical methods are used to identify and assess the material. If your internal specification requires a particular purity or impurity profile, state it explicitly during the inquiry rather than treating an illustrative target as a guaranteed product grade.
Information to Request
- Product name, CAS number, molecular formula, and molecular weight as stated in the supplier’s technical documents.
- Lot-specific certificate of analysis, including the reported assay or purity and the method used.
- Available identification data, such as relevant chromatographic or spectroscopic results, where provided.
- Recommended storage, handling, packaging, and transport information for the offered material.
- Any known limitations, handling precautions, or documentation requirements relevant to your application.
Buyer Selection Framework
A reliable purchase decision combines chemical identity, quality evidence, supply fit, and commercial terms. First, confirm that CAS 22428-87-1 and the product name on the quotation align with your required material. Next, review the available batch documentation against your own acceptance criteria, including whether the analytical method is suitable for your quality system.
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Evaluate Quality and Documentation
Ask whether the supplier can provide a specification before ordering and batch-specific documents before or with shipment. Check that the reported test results have clear units or acceptance limits where applicable, and clarify any points that are not defined. If your organization requires particular declarations or document formats, confirm availability in writing because support can vary by product, shipment, and destination.
Plan Quantity and Scale-Up
Start with the quantity needed for your evaluation and confirm whether a sample or small pack is available. A sample request of 10–25 g can be used as a planning example for preliminary laboratory assessment, not as a guaranteed pack size or standard offer. For scale-up, provide the expected demand, target delivery window, destination, and any packaging constraints so the supplier can assess feasibility.
Pricing, MOQ, and Lead Time
Price, minimum order quantity, and lead time should be confirmed in a current quotation; they are not fixed solely by the CAS number. They may depend on requested quantity, availability, packaging, analytical or documentation requirements, and shipping destination. Ask the supplier to state the quote validity, shipment basis, estimated dispatch timing, and any conditions that could affect delivery.
For a meaningful comparison, request quotations on the same basis from each potential source. Compare not only the unit price but also the offered specification, documentation, pack size, and delivery terms. If your project schedule is critical, confirm the timeline before placing an order and ask whether the quoted material is available for the requested quantity.
Supplier Evaluation Checklist
Use the following checklist to structure supplier discussions and reduce avoidable sourcing ambiguity. The answers should be specific to the product and proposed lot rather than based on general company statements. If a requirement is essential to your application, record it in the inquiry and confirm the supplier’s response before purchase.
- Can the supplier confirm the product identity as 4-Hydroxycyclohexanone ethylene acetal, CAS 22428-87-1?
- Is a current specification available, and can the supplier provide a lot-specific certificate of analysis?
- Are the offered purity, analytical methods, packaging, and quantity aligned with your requirements?
- Can the supplier confirm the current MOQ, price basis, availability, and estimated lead time?
- Can requested shipping, handling, and destination-specific documents be discussed before order confirmation?
How Maison Chemical Can Support Your Inquiry
At Maison Chemical, we support B2B inquiries for 4-Hydroxycyclohexanone ethylene acetal CAS 22428-87-1 as a chemical supplier. To help us assess a request, include your required quantity, destination, intended grade or specification, and any documentation needs. We can then confirm the applicable product information, commercial terms, and supply options available for your inquiry.
For development or scale-up purchasing, sharing your acceptance criteria at the quotation stage can help clarify whether the offered material meets your requirements. If you need a sample, specific packaging, or additional documentation, identify those needs in your initial message. Availability and support should be confirmed for each order rather than assumed.
Conclusion: Practical Next Steps for Buyers
4-Hydroxycyclohexanone ethylene acetal CAS 22428-87-1 is a protected cyclohexanone building block with a free hydroxyl group, and its potential value depends on the chemistry and quality requirements of the intended route. Its commonly associated identifiers are formula C8H14O3 and calculated molecular weight approximately 158.20 g/mol; these should be checked against supplier documentation. Before purchasing, confirm identity, review batch-specific analytical information, and assess compatibility with your process.
Your next step is to send Maison Chemical your required quantity, destination, desired specification, and documentation expectations for a quotation. Confirm current price, MOQ, lead time, and pack options in writing before placing an order. This approach gives your team a clear basis for evaluating both the material and the supply proposal.