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Our Members Asked:

Butyrate Supplements for Gut Health: Does butyric acid really work and is it safe?

Answer:

Butyrate supplements are promoted for a wide range of digestive health benefits, from improving overall gut health to decreasing symptoms of irritable bowel syndrome, as well as Crohn's disease and ulcerative colitis. They are also promoted for improving blood sugar and insulin function, promoting weight/fat loss, and for more general benefits such as decreasing inflammation, boosting the immune system, and increasing energy. Several small preliminary trials suggest potential benefits, but there is not enough evidence to prove that butyrate supplements do all that they promise.

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+ — 19 sources

In addition the results of its expert testing, ConsumerLab uses only high-quality, evidence based, information sources. These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. On evolving topics, studies from pre-print journals may be sourced. All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. We continually update and medically review our information to keep our content trustworthy, accurate, and reliable. The following sources are referenced in this article:

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• Bedford, Anim Nutr
• Bourassa, Neurosci Letters
• Coppola, JAMA Netw Open
• Govindarajan, J Alzheimers Dis
• Haran, mBio
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Butyrate, also known as butyric acid, is a short-chain fatty acid (SCFA) that is crucial for colon health and overall well-being. It is primarily produced through the fermentation of dietary fibers by anaerobic bacteria in the human gut, such as Faecalibacterium prausnitzii, Eubacterium, and members of the genus Roseburia. Butyrate serves as a major energy source for colonocytes, promotes a healthy intestinal lining, and possesses anti-inflammatory properties. It also plays a role in regulating gene expression, cell differentiation, and apoptosis, which are important for preventing colorectal cancer.

Role of butyrate in human health

1. Colon Health and Cancer Prevention: Butyrate is the primary energy source for colonocytes and promotes a healthy colon by maintaining mucosal integrity and reducing inflammation. It has been shown to inhibit the growth of colon cancer cells.
2. Anti-inflammatory Properties: Butyrate exerts anti-inflammatory effects by inhibiting nuclear factor kappa B (NF-κB) and modulating cytokine production in the gut, which helps in managing inflammatory bowel disease (IBD) and other inflammatory conditions.
3. Gut Barrier Function: Butyrate strengthens the intestinal barrier by enhancing the production of tight junction proteins. This function is crucial in preventing the translocation of harmful substances from the gut into the bloodstream.
4. Energy Metabolism: Butyrate influences energy metabolism by acting as a signaling molecule, affecting cellular processes, energy expenditure, and insulin sensitivity.
5. Neurological Effects: Emerging evidence suggests that butyrate can influence brain health through the gut-brain axis, impacting behavior and potentially alleviating symptoms of neurological disorders.

Fun fact about butyrate

There is a small amount of naturally occurring butyric acid in butter, and the name “butyric” is derived from it because butyric acid contributes to the distinct taste and aroma of butter. In high concentrations, butyrate can have a pungent and unpleasant odour, reminiscent of rancid butter. However, in smaller amounts, it adds a pleasant, creamy, and buttery flavour to foods. The Chuckling Goat kefir is really rich in butyric acid. This contributes to its powerful taste!

Where to find your butyrate score in the Chuckling Goat Gut Microbiome Test

The Chuckling Goat Gut Microbiome Test features your butyrate score in the postbiotics report.

Important disclaimer

The Chuckling Goat Gut Microbiome Handbook is an educational resource built to translate complex science into plain English. The information provided on this page is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your GP or other qualified health provider with any questions you may have regarding a medical condition. Always check with your GP for interactions with medications/health conditions before changing your diet or starting to take food supplements.

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