Collagen, often hailed as the “glue” that holds our bodies together, is a crucial protein for maintaining skin, joints, and connective tissues. While collagen is widely known, the science behind fish collagen and how it works deserves exploration. Fish collagen peptide is a distinctive and valuable ingredient for overall health and wellness.
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It is derived from the pristine sources of fish skin, scales, and bones, the natural and bioactive compound offers a myriad of benefits for the human body. The unique helical structure and high bioavailability, hydrolyzed fish collagen peptide has become a focal point in various applications such as pharmaceuticals, nutraceuticals, skincare, and more. Let’s explore more about the science behind fish collagen peptide, its mode of action, benefits in skin & joint health, and how is it different from collagens derived from other sources.
Collagen is a fibrous protein with a triple helical structure, characterized by three polypeptide chains intertwined like a rope. Fish collagen, specifically derived from the scales, skin, or bones of fish, possesses a unique amino acid profile compared to other collagen sources such as bovine or porcine. The primary amino acids in fish collagen include glycine, proline, and hydroxyproline which are essential for collagen’s stability and function.
The helical structure of fish collagen peptides contributes to several beneficial properties, making it a popular ingredient in various applications. Here are some of the key benefits associated with the helical structure of fish collagen peptides:
Upon consumption, fish collagen undergoes a series of processes within the body that facilitate its incorporation into the skin, joints, and other connective tissues. The digestive system breaks down fish collagen into smaller peptides through the action of enzymes like collagenase and peptidases. These peptides are then absorbed into the bloodstream, circulating and reaching target tissues.
One remarkable aspect of fish collagen is its bioavailability, referring to the extent and rate at which a substance is absorbed and becomes available for use in the body. Fish collagen peptides are known for their high bioavailability, meaning they are efficiently absorbed and utilized by the body compared to some other collagen sources.
Several factors contribute to the impressive absorption rates and bioavailability of fish collagen. The smaller size of marine fish collagen peptides, resulting from the hydrolysis process during production, plays a crucial role. The reduced molecular weight allows easier absorption through the intestinal barrier, enhancing the delivery of collagen peptides to target tissues.
Moreover, the composition of amino acids in fish collagen contributes to its bioavailability. The abundance of glycine facilitates rapid absorption. Studies have shown that fish collagen peptides reach higher levels in the bloodstream than other collagen types, making them an efficient choice for those seeking collagen supplementation.
Fish collagen is used for its potential benefits in addressing various skin and joint health issues. While individual responses can vary, here are some common problems in skin and joint health that fish collagen may potentially help address:
Numerous scientific studies have explored the efficacy of fish collagen in promoting skin health, joint function, and overall well-being. These studies provide valuable insights into the mechanisms through which fish collagen exerts its beneficial effects.
A study published in the Journal of Cosmetic Dermatology () investigated the effects of fish collagen peptides on skin hydration and elasticity. The results indicated a significant improvement in skin hydration and elasticity, suggesting that fish collagen supplementation could contribute to enhanced skin moisture and reduced signs of aging.
Research published in Marine Drugs () explored the potential of fish collagen in wound healing. The study demonstrated that fish collagen promoted cell migration and collagen synthesis, accelerating the wound-healing process. This suggests that fish collagen may not only benefit skin health but also support the body’s natural healing mechanisms.
A clinical trial published in the International Journal of Molecular Sciences () investigated the impact of fish collagen peptides on joint pain and function in individuals with osteoarthritis. The results indicated a significant reduction in joint pain and improved joint function in the group receiving fish collagen peptides, highlighting its potential as a supportive therapy for joint health.
Collagen is a structural protein found in the connective tissues of animals, and collagen supplements are derived from various sources. Fish collagen is one type of collagen that is distinct from collagen derived from other sources. Here are some key differences between fish collagen and collagen from other sources:
The science behind fish collagen reveals a protein with a unique structure and exceptional bioavailability. The triple helix structure, amino acid composition, and hydrolysis process during production contribute to the effectiveness of fish collagen in promoting skin health, supporting joint function, and aiding in wound healing.
Scientific studies provide substantial evidence supporting the efficacy of fish collagen, further reinforcing its potential as a valuable supplement for those seeking to enhance overall well-being. As we continue to unravel the mysteries of collagen and its applications, fish collagen stands out as a promising option backed by cutting-edge research. Whether you’re interested in maintaining youthful skin or supporting joint health, understanding the science behind fish collagen empowers you to make informed choices for a healthier, more vibrant life.
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Collagen is THE main component of our skin, at around 80%. Together with elastin, collagen forms the supporting corset that gives our skin and the underlying connective tissue firmness and elasticity. In addition, collagen also has plumping effects due to its water-binding properties.
From the age of around 25, the body’s own collagen production begins to decline by about 1.5% per year, leading to ever more visible changes. From this age onwards, the targeted intake of hydrolysed collagen is therefore worthwhile and is an ideal strategy to counteract natural skin ageing and to nurture the beauty of the sensitive outer barrier from within.
Hydrolysed collagen enters the small intestine when taken orally, where it is absorbed into the bloodstream in the form of small collagen peptides and free amino acids. It thus has a dual effect.
While in the beauty world, nothing beats collagen hydrolysate, peptide powder is still considered a secret tip among athletes. Although there are isolated studies on muscle growth for collagen hydrolysate that demonstrate a benefit for fat-free mass and strength, there are certainly more suitable sources of protein specifically for muscle growth. Nonetheless, collagen hydrolysate is a good suggestion for athletes for the regeneration and strengthening of their musculoskeletal system. More about this in the following point.
Collagen is always found where the tissue has to withstand high tensile stress – whether in muscles, ligaments, tendons or cartilage. These structures are subject to enormous forces, particularly when under sporting stress. The fact that the targeted use of collagen hydrolysate not only strengthens the collagen-dependent structures of the musculoskeletal system, but in certain cases can be useful even in the case of already existing problems, has been shown, among other things, by a randomised placebo-controlled interventional study. In this study, 147 athletes with arthritis-related joint pain received either collagen hydrolysate (10 g daily) for 24 weeks or a placebo. After the end of the study, the results analysis showed that there was a partially significant reduction in pain in the collagen hydrolysate group.
The branded raw material NATICOL® has undergone a variety of clinical studies with a beauty focus, which were conducted in collaboration with research institutes as well as specialist clinics and hospitals.
A double-blind, randomised and placebo-controlled study published in investigated the anti-ageing potential of 5 g Naticol® fish collagen peptides in 60 healthy female subjects aged 35 to 70 years. The test zones included the facial skin, abdominal skin and forearm skin.
After 8 weeks of regular intake of 5 g Naticol®, significant improvements in skin firmness on the abdomen, face and forearms as well as a reduction in wrinkles were found. The results also suggested that Naticol® could have a preventive effect against dehydration in cold weather conditions.
For more information, please visit hydrolyzed fish collagen manufacturers.
Would you like to dive even further into the subject and read more in studies on collagen or collagen hydrolysate? Under the item "In-depth studies", you will find some of the studies that we consulted in our various collagen research.
Conclusion: Collagen is not only a beauty booster for our skin, it also benefits our muscles, cartilage and tendons. If you want to get the most out of the various benefits of structural protein, collagen hydrolysate from fish is to be particularly recommended. This is not only considered easy to digest and absorb, it also mainly supplies the highly sought-after type I collagen in a particularly bioavailable peptide form.
Further reading:
Asserin, J. et al. . The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. Dec;14(4):291-301. doi: 10./jocd.. Epub Sep 12. https://pubmed.ncbi.nlm.nih.gov//
Choi, F.D. . Oral Collagen Supplementation: A Systematic Review of Dermatological Applications. J Drugs Dermatol. Jan 1;18(1):9-16. https://pubmed.ncbi.nlm.nih.gov//
De Miranda, R.B. et. al. . Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis. Int J Dermatol. Dec;60(12):-. doi: 10./ijd.. Epub Mar 20. https://pubmed.ncbi.nlm.nih.gov//
Evans, M. et al. . A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. Journal of Cosmetic Dermatology. 20(3):825–834. https://pubmed.ncbi.nlm.nih.gov//
Sibilla, S. et al. . An Overview of the Beneficial Effects of Hydrolysed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies. The Open Nutraceuticals Journal. 8(1). https://pubmed.ncbi.nlm.nih.gov//
De Almagro, M. C. . The Use of Collagen Hydrolysates and Native Collagen in Osteoarthritis. AJBSR. 7(6):530–532. https://pubmed.ncbi.nlm.nih.gov//
Hong, H. et al. . Preparation of low-molecular-weight, collagen hydrolysates (peptides): Current progress, challenges, and future perspectives. Food Chemistry. 301:. https://pubmed.ncbi.nlm.nih.gov//
Campos Mbg, P. M. . An Oral Supplementation Based on Hydrolyzed Collagen and Vitamins Improves Skin Elasticity and Dermis Echogenicity: A Clinical Placebo-Controlled Study. Clin Pharmacol Biopharm. 04(03). https://www.researchgate.net/publication/_An_Oral_Supplementation_Based_on_Hydrolyzed_Collagen_and_Vitamins_Improves_Skin_Elasticity_and_Dermis_Echogenicity_A_Clinical_Placebo-Controlled_Study
Castillo-Briceño, P. et al. . A role for specific collagen motifs during wound healing and inflammatory response of fibroblasts in the teleost fish gilthead seabream. Mol Immunol. 48(6–7):826–834. https://pubmed.ncbi.nlm.nih.gov//
Geahchan, S. et al. . Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration. Mar Drugs. 20(1):61. https://pubmed.ncbi.nlm.nih.gov//
Duteil, L. et al. . SPECIFIC NATURAL BIOACTIVE TYPE 1 COLLAGEN PEPTIDES ORAL INTAKE REVERSE SKIN AGING SIGNS IN MATURE WOMEN. J Aging Res & Lifestyle. :1–9. https://www.jarlife.net/-specific-natural-bioactive-type-1-collagen-peptides-oral-intake-reverse-skin-aging-signs-in-mature-women.html
Lugo, J. P. et al. . Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: A multicenter randomized, double-blind, placebo-controlled study. Nutr J. Jan 29;15:14. doi: 10./s-016--8. https://pubmed.ncbi.nlm.nih.gov//
Zdzieblik, D. et. al. . Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. Oct 28;114(8):-45. doi: 10./S. Epub Sep 10. https://pubmed.ncbi.nlm.nih.gov//
Mohammed A., He S. . A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy of a Hydrolyzed Chicken Collagen Type II Supplement in Alleviating Joint Discomfort. Nutrients. Jul 18;13(7):. doi: 10./nu. https://pubmed.ncbi.nlm.nih.gov//
Li W, Sun K, Ji Y, Wu Z, Wang W, Dai Z, Wu G. Glycine Regulates Expression and Distribution of Claudin-7 and ZO-3 Proteins in Intestinal Porcine Epithelial Cells. J Nutr. May;146(5):964-9. doi: 10./jn.115.. Epub Mar 30. PMID: . https://pubmed.ncbi.nlm.nih.gov//
Howard A, Tahir I, Javed S, Waring SM, Ford D, Hirst BH. Glycine transporter GLYT1 is essential for glycine-mediated protection of human intestinal epithelial cells against oxidative damage. J Physiol. Mar 15;588(Pt 6):995-. doi: 10./jphysiol... Epub Feb 1. PMID: ; PMCID: PMC https://pubmed.ncbi.nlm.nih.gov//
Wu G, Bazer FW, Burghardt RC, Johnson GA, Kim SW, Knabe DA, Li P, Li X, McKnight JR, Satterfield MC, Spencer TE. Proline and hydroxyproline metabolism: implications for animal and human nutrition. Amino Acids. Apr;40(4):-63. doi: 10./s-010--z. Epub Aug 10. PMID: ; PMCID: PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC/
Zhu S, Huang M, Feng G, Miao Y, Wu H, Zeng M, Lo YM. Gelatin versus its two major degradation products, prolyl-hydroxyproline and glycine, as supportive therapy in experimental colitis in mice. Food Sci Nutr. Apr 16;6(4):-. doi: 10./fsn3.639. PMID: ; PMCID: PMC. https://pubmed.ncbi.nlm.nih.gov//
Asserin, Jérome et al. . The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Journal of cosmetic dermatology vol. 14,4 (): 291-301. doi:10./jocd. https://pubmed.ncbi.nlm.nih.gov//
Damodarasamy, Mamatha et al. . Hyaluronan enhances wound repair and increases collagen III in aged dermal wounds. Wound repair and regeneration: official publication of the Wound Healing Society [and] the European Tissue Repair Society vol. 22,4 (): 521-6. doi:10./wrr. https://pubmed.ncbi.nlm.nih.gov//
Clark, K.L., et al. . 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. May;24(5):-96. doi: 10./×. https://pubmed.ncbi.nlm.nih.gov//
Dressler, P. et al. . Improvement of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability. J Sports Sci Med. Jun; 17(2): 298–304. https://pubmed.ncbi.nlm.nih.gov//
Oertzen-Hagemann, V., et al. . Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Skeletal Muscle Proteome in Recreationally Active Men. Nutrients, 11(5). https://pubmed.ncbi.nlm.nih.gov//
Kirmse, M., et al. . Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally Active Men. Nutrients, 11(5). https://pubmed.ncbi.nlm.nih.gov//
Lebensmittelchemische Gesellschaft. : https://www.gdch.de/fileadmin/downloads/Netzwerk_und_Strukturen/Fachgruppen/Lebensmittelchemiker/Arbeitsgruppen/kosmetik/db_proteine1.pdf, Zugriff: 1.10.
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