4-Aminophenylboronic acid picol ester, CAS 214360-73-3, is an aryl boronic ester building block used mainly in synthetic and medicinal chemistry research. Its structure combines a para-aminophenyl group with a protected boron center in a picol ester form. This combination gives chemists a useful platform for palladium-catalyzed cross-coupling and for preparing more complex aromatic molecules. At Maison Chemical, I support buyers by focusing on identity confirmation, application fit, documentation, packaging, and dependable supply rather than relying on a name alone.
In practical terms, this compound is a protected aryl boronic acid derivative. The boron-containing portion is converted into a picol ester, while the aromatic ring carries an amino group at the 4-position relative to the boron substituent. The para-amino functionality can provide an additional site for downstream derivatization, subject to the reaction conditions selected by the chemist.
The picol ester form is important because boronic acids and boronic esters can show different handling, weighing, solubility, and reaction behavior. A protected ester may be more convenient for storage and synthetic planning than the corresponding free boronic acid, although the best choice depends on the reaction system. I recommend confirming the exact structural representation, molecular formula, molecular weight, and analytical data against the supplier’s current specification before ordering.
CAS 214360-73-3 identifies the substance referenced by the product name, but the CAS number alone does not establish purity, residual solvent content, water content, particle size, or suitability for a specific reaction. Those factors must be confirmed through a specification sheet and, where appropriate, a lot-specific certificate of analysis. I therefore treat the CAS number as an identity starting point rather than a complete quality assessment.
The main synthetic value of 4-aminophenylboronic acid picol ester comes from its aryl boronate functionality. Under suitable catalytic and base conditions, aryl boronic esters are commonly used as coupling partners in carbon–carbon and carbon–heteroatom bond-forming reactions. The exact performance depends on the catalyst, solvent, base, temperature, substrate compatibility, and protection state of the amino group.
The amino group also creates an opportunity for further functionalization. Depending on the project, chemists may protect, acylate, alkylate, or otherwise modify the amine before or after a coupling step. I advise users to consider chemoselectivity early, because an unprotected amino group can interact with catalysts, bases, electrophiles, or activated intermediates.
I most often position this material for research laboratories developing substituted aromatic compounds. It can be relevant to pharmaceutical discovery, agrochemical research, materials chemistry, and custom organic synthesis when the target structure requires a para-amino aryl fragment. Its value is especially clear when a project needs modular bond construction rather than a long linear synthesis.
For an early feasibility study, a chemist may evaluate the substrate on a representative scale such as 0.1–1.0 mmol before committing to larger quantities. This is a planning range, not a guaranteed reaction condition or performance claim. The resulting experiment should be assessed using the project’s normal analytical methods, such as chromatography, NMR spectroscopy, or mass spectrometry.
| Project requirement | Why this material may be considered | What I recommend checking |
|---|---|---|
| Aryl coupling development | Provides a protected aryl boronate handle | Catalyst, base, solvent, and substrate compatibility |
| Medicinal chemistry diversification | Combines a coupling site with an amino-functionalized aromatic ring | Amine protection strategy and purification behavior |
| Scale-up planning | Can serve as a defined intermediate for process evaluation | Lot consistency, impurity profile, packaging, and supply continuity |
Buyers may encounter this product in different package sizes, purity grades, and documentation levels. The correct choice depends on whether the material is being used for method discovery, repeated library synthesis, process research, or a regulated development workflow. A small research pack can reduce initial inventory exposure, while a larger pack may simplify continuity after the route has been confirmed.
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I recommend reviewing at least the chemical name, CAS number, appearance, assay or purity method, water content where relevant, residual solvents, storage guidance, and batch identification. If the supplier provides an analytical package, I also review the available chromatographic and spectroscopic information before approving the material for a project. A specification should describe the actual release criteria rather than use only broad terms such as “high purity.”
As with many boron-containing organic intermediates, the product should be handled according to its current safety data sheet and laboratory risk assessment. A controlled storage condition such as 2–8 °C may be appropriate when specified by the supplier, but I do not treat that range as universal without checking the product documentation. Moisture exposure, repeated opening, incompatible chemicals, and unlabelled secondary containers should be avoided.
For routine laboratory work, I suggest allowing the container to reach room temperature before opening when condensation could be a concern, then resealing it promptly. “Room temperature” is commonly interpreted as approximately 20–25 °C for planning purposes, but the supplier’s storage instruction takes precedence. Users should also confirm whether inert-gas handling or additional moisture protection is needed for their specific application.
The best supplier is not necessarily the one offering the lowest price per gram. I evaluate chemical identity, batch evidence, packaging suitability, minimum order quantity, lead-time transparency, and the supplier’s ability to communicate about technical questions. For a project with several synthesis cycles, continuity and document quality can be as important as the initial quotation.
I also recommend separating “identity risk” from “application risk.” A material can meet its stated specification and still require reaction optimization because catalysts, bases, solvents, and substrates vary between laboratories. Conversely, a promising reaction result does not replace the need for proper identity and batch documentation.
At Maison Chemical, I approach this product as a supply and technical communication requirement rather than a simple catalogue transaction. I can help buyers organize requests around CAS verification, intended use, quantity, packaging, destination, and documentation needs. This makes it easier to provide a quotation that reflects the actual purchasing scenario.
For organizations moving from exploratory synthesis to repeat procurement, I also recommend agreeing on a clear specification before the first purchase. Depending on the project, the document package may include a product specification, certificate of analysis, safety data sheet, packing information, and shipping documentation. I do not claim a universal lead time or purity level without confirming the current batch and order details.
So, what is 4-Aminophenylboronic acid picol ester CAS 214360-73-3? It is a useful research intermediate that combines a protected aryl boronate with a para-amino functional group, making it relevant to cross-coupling, medicinal chemistry, and broader organic synthesis programs. Its suitability must be confirmed against the intended reaction, required specification, and handling conditions.
My recommended next step is to prepare a concise inquiry stating the required quantity, target application, destination, package preference, and documentation expectations. Maison Chemical can then review availability, specification details, packaging, and commercial terms for your project. Contact us for a product quotation or technical purchasing discussion based on your actual B2B requirements.
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